Gene: PPARG ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs4135352
rs4135352
PPARG
0.010 GeneticVariation BEFREE The single nucleotide polymorphisms (SNPs) of the above genes, such as GNB3-C825T, ADRB3-Trp64Arg, UCP2-3'UTR 45 bp del/ins, and PPARγ-Pro12Ala, are associated with obesity and body mass index. 24827746

2014
dbSNP: rs3856806
rs3856806
PPARG
0.070 GeneticVariation BEFREE The ProAla+AlaAla genotypes of PPAR-γ Pro12Ala were significantly associated with higher risk of obesity while C1431T polymorphism did not show any significant association. 22410809

2012
dbSNP: rs3856806
rs3856806
PPARG
0.070 GeneticVariation BEFREE The C1431T polymorphism in peroxisome proliferator-activated receptor-γ (PPARγ) has been shown to be associated with diabetes, obesity, and metabolic syndrome. 21643757

2012
dbSNP: rs3856806
rs3856806
PPARG
0.070 GeneticVariation BEFREE The novel variants were, together with Pro12Ala and 1431C>T, examined for relationships with obesity among 234 men with early-onset obesity with a BMI at age approximately 20 years of 33.2+/-2.5 kg/m2 and 323 nonobese men with a BMI of 21.7+/-2.5 kg/m2, who were also reexamined after approximately 29 years. 15976135

2005
dbSNP: rs3856806
rs3856806
PPARG
0.070 GeneticVariation BEFREE The association of the C1431T silent mutation and the Pro12Ala missense transversion within the PPARgamma gene with the development of T2DM or obesity has often yielded contradictory results. 18250615

2007
dbSNP: rs3856806
rs3856806
PPARG
0.070 GeneticVariation BEFREE Our results support an important association between rs1805192 and rs3856806 minor allele (G allele) of PPARG and increased T2DM risk, the interaction analysis shown a combined effect of G- obesity interaction between rs1805192 and obesity on increased T2DM risk. 28123453

2017
dbSNP: rs3856806
rs3856806
PPARG
0.070 GeneticVariation BEFREE Mothers homozygous for the T allele of C1431T were also more obese (24 vs. 9%, P = 0.035), and three times more had gestational diabetes (18 vs. 6%, P = 0.044). 21795447

2011
dbSNP: rs3856806
rs3856806
PPARG
0.070 GeneticVariation BEFREE Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations. 19805902

2009
dbSNP: rs1822825
rs1822825
PPARG
0.010 GeneticVariation BEFREE Although gender, body mass index (BMI), serum total cholesterol concentration, or protein intake per day were statistically associated with hyperuricemia, the combination of BMI, gender, and rs1822825, rather than that of age, serum lipid profile, blood pressure, and protein intake per day, satisfied the predictability for hyperuricemia (sensitivity: 69.3%; specificity: 83.7%) in Taiwan-born obese Han Chinese. 23237621

2013
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE Our research has confirmed an association between the pro12ala allele and reduced incidence of obesity in pre-pubertal children and there are strong associations between genetic variation at the PPARG locus and percentage body fat. 16777151

2006
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE Among obese people, there was no association between any of the T2Dm or obesity-related traits and the Pro12Ala polymorphism. 16050954

2005
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population. 11248748

2001
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE Our results showed that the Pro12Ala polymorphism is not associated with childhood or adult obesity in the French Caucasian population. 15784141

2005
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE Concurrently, genotyping of the Pro12Ala polymorphism showed that obese subjects possess a significantly higher frequency of the Pro/Pro genotype than nonobese controls (90.5 vs 79.5%; P = 0.03), suggesting that this genotype is involved in an increased risk of obesity in the Tunisian population. 23315125

2013
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE The Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma (PPARG) gene in relation to obesity and metabolic phenotypes in a Taiwanese population. 25182148

2015
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE Beta3AR Trp64Arg and PPARgamma2 Pro12Ala polymorphisms might be associated with insulin resistance and obesity, and there might be slight synergistic effects between this two gene loci, and further studies are necessary to confirm this finding. 17624182

2007
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE The Pro12Ala polymorphism in exon B of peroxisome proliferator-activated receptor gamma 2 (PPAR gamma 2) gene has been related to obesity, insulin resistance, and risk of type 2 diabetes. 14981210

2004
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE In conclusion, the higher frequency of the C-->T substitution in exon 6 of the PPAR-gamma gene in PCOS women suggests that it plays a role in the complex pathogenetic mechanism of obesity in PCOS, whereas the Pro(12)Ala polymorphism does not seem to affect BMI in PCOS women. 14671186

2003
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE The present study provides evidence that the Pro12Ala polymorphism of the PPARgamma-2 gene is associated with obesity in non-diabetic men from Tunisian origin. 19733160

2009
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE Association between PPARγ2 Pro12Ala polymorphism and myocardial infarction and obesity in Han Chinese in Hohhot, China. 22653647

2012
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE Further studies of the Pro12Ala variant will determine its relevance to obesity, insulin resistance, and type 2 diabetes. 9425261

1997
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE The combined results showed that PPAR-γ Pro1</span>2Ala polymorphism was associated with the obesit</span>y risk (Ala vs. 25502405

2015
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE These results suggest that the Pro12Ala mutation in PPARgamma is not associated with either diabetes or obesity and may not be an important determinant of obesity or diabetes in Korean subjects. 10843155

2000
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE Interaction between Pro12Ala polymorphism of PPARγ2 and diet on adiposity phenotypes. 25342491

2014
dbSNP: rs1805192
rs1805192
PPARG
0.100 GeneticVariation BEFREE There was also no significant relationship between dyslipoproteinemia or obesity and the PPARgamma2 Pro12Ala genotype. 9918859

1999